Oral Melanotic Macule: Symptoms and Treatment Skinsight Mystery behind labial and oral melanotic macules: Clinical, dermoscopic and pathological aspects of Laugier Hunziker syndrome Spotty lips. These are labial melanotic macules, kinda like freckles on the lips. They are mostly due to age and sun exposure, but sometimes they run in families and are associated with AD :: Annals of Dermatology Labial Macules: Dark Spots on the Lip Dermatology Advisor