Coffee Enemas in Toronto How do Coffee Enemas work? Coffee Enema and Erectile Dysfunction: What the Evidence Actually Shows Ozonating coffee enemas combines two powerful therapies. The coffee stimulates hepatic glutathione S transferase, upregulating detoxification pathways in the liver. It also increases glutathione Coffee enemas probably won't detox your system they're more likely to cause you serious damage Glutathione fermentation by Millerozyma farinosa using spent coffee grounds extract and seawater ScienceDirect