Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Frontiers Potential adverse actions of prenatal exposure of acetaminophen to offspring Tylenol and Glutathione: A Closer Look At Their Relationship Acetaminophen and Neurodevelopmental Disorders: What Studies Are Showing Anna Anderson Homeopath I'm Dr Ashley Mayer . I'm a practicing integrative physician, and also a mama to two great kiddos of my own! If you caught my post on Ibuprofen a few days ago,