Sermorelin vs Ipamorelin: Which Is Better for You? Peptide side effects no one talks about BPC 157 headaches. TB 500 fatigue. CJC Ipamorelin water retention. Most people quit. But 90% of the time it's the protocol, not the peptide. Tesamorelin vs. Sermorelin: Peptides to Boost HGH CJC 1295 + Ipamorelin Sculpt Your Body and Boost Energy If youre looking at peptides to boost growth hormone, heres the key difference: Growth hormonereleasing peptides (GHRPs), like Ipamorelin, work by hitting the ghrelin receptor, your bodys hunger