The biochemical pathway that makes BH4 requires GTP as the substrate and three dedicated enzymes (GTP cyclohydrolase I, 6pyruvoyltetrahydropterin synthase, and sepiapterin reductase); the key redox cofactors used in the pathway and Flavin adenine dinucleotide (FAD) activates the glutathione reductase Download Scientific Diagram Harnessing the Mechanism of Glutathione Reductase for Synthesis of Active Site Bound Metallic Nanoparticles and Electrical Connection to Electrodes Journal of the American Chemical Society Glutathione reductase Wikipedia Evolution of Function in the Two Dinucleotide Binding Domains Flavoproteins PLOS Computational Biology
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