Cagrilintide is an amylin analogue that helps regulate appetite. In a randomized trial of over 3400 patients who were overweight or obese and had 1 weight related complication, individuals assigned to a combination Combined GLP 1 amylin analog bests monotherapy for HbA1c drop, weight loss in diabetes In the REDEFINE 2 phase 3a trial involving adults with obesity and diabetes, the use of cagrilintidesemaglutide resulted in a significantly lower body weight than placebo at 68 weeks. Full trial results Incretin based therapies for the treatment of obesity related diseases npj Metabolic Health and Disease Exciting ADA 2025 Trial Updates with CagriSema
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coadministered cagrilintide and semaglutide in adults with overweight or obesity Efficacy and safety of co-administered once-weekly cagrilintide 2·4 mg with once-weekly semaglutide 2·4 mg in type 2 diabetes: a multicentre, randomised, double-blind, active-controlled, phase 2 trial