Tylenol depletes glutathione your livers most important protective antioxidant. Every dose chips away at it., So instead of taking lower doses every 46 hours, I recommend spacing to 1000mg every 8 Regarding Tylenoland Critical Thinking in Matters of Health. Apex Dental Acetaminophen Pathway (toxic doses), Pharmacokinetics View of Acetaminophen, the missing anion gap in the patient with metabolic acidosis The Southwest journal of medicine Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect